Prior to the NFL season, nobody on Earth would’ve predicted the Tennessee Titans’ season would be blown to smithereens in Week 5.

The Colts will face a desperate and dangerous Jeff Fisher led Titans' team Sunday night.

The Colts will face a desperate and dangerous Jeff Fisher led Titans' team Sunday night.

A loss to the Colts Sunday night and that’s exactly what will happen to the 0-4 Titans.

An 0-5 team has never made the playoffs, and the Titans won’t be the first.

However, burying the Titans is easier said than done.

The Colts have lost two of their last three in Nashville and face a desperate Titans’ team.

And despite their 0-4 record the Titans lost their first three contests by a combined 13 points – all at the hands of potential playoff teams in the Steelers, Texans, and Jets.

While the season has been a disaster for the Titans, they still hold the Colts’ kryptonite – a top-notch running game.

The Titans rank seventh in rushing and can beat you with Chris Johnson’s speed or LenDale White’s power.

Tennessee head coach Jeff Fisher isn’t going down without a fight and will pull out all the stops Sunday. Expect a Vince Young sighting, a gutsy fourth-down call, and a surprise in the kicking game – whether it be an onside kick, a fake, or a reverse on a return.

But will homefield advantage, a lethal running game, and some Fisher shenanigans be enough for the Titans?

Maybe not.

The Titans’ defense – which ranked seventh in the league last year – has been ripped to shreds this season. Injuries and the absence of Albert Haynesworth have contributed, but there’s no explanation for this unit’s total collapse.

Tennessee ’s defense ranks 22nd overall dead least against the pass, allowing 282 yards per game and 10 touchdowns so far.

That’s bad news when Peyton Manning is in town.

Manning is off to arguably the best start of his career. He currently leads the league in passing yards (1,336), passer rating (114.5), touchdowns (9), and is completing 70.8 percent of his passes.

Last week David Garrard carved the Titans defense for 323 yards and two touchdowns – makes you think what Manning might be able to do.

With a win, the Colts will deliver the knockout punch to the defending division champs. That opportunity doesn’t come around too often … especially in early October.