Few are giving the Jacksonville Jaguars a puncher’s chance in Indianapolis this Sunday, but they should.

Maurice Jones-Drew has feasted on the Colts D throughout his career ... no reason to think Sunday will be any different.

Maurice Jones-Drew has feasted on the Colts D throughout his career ... no reason to think Sunday will be any different.

While the preseason means nothing, the Colts’ defense comes into the season with some glaring issues.

Bob Sanders and Kelvin Hayden got no field action in the preseason, while Marlin Jackson, Robert Mathis, Raheem Brock, and Antoine Bethea saw virtually none.

At no point during the preseason were the Colts able to march out a defensive lineup that even resembled their starting 11.

Some defenses could probably get away with that, but not this one.

Not a defense with Bob Sanders on the shelf (surprise, surprise) and both corners — Marlin Jackson and Kelvin Hayden — fighting their way back to health.

Not a defense featuring a pair of starting defensive tackles that were signed off waivers or practice squads – Daniel Muir and Antonio Johnson.

Not a defense with a pair of unproven starting outside linebackers — Tyjuan Hagler and Clint Session — and an aging middle linebacker coming back from a broken leg — Gary Brackett.

Not a defense with a new coordinator whose last stint at the position was in 2006 — Larry Coyer.

The Colts’ defense enters the season with major question marks. And say what you will about the Jaguars, but they know how to run the ball … particularly against the Colts. You can bet they’ll do it early and often on Sunday.

With an offensive line in complete shambles and a running game that struggled (18th in the NFL), the Jaguars still had no trouble pilling up yards on the ground against the Colts last season — in their two matchups the Jaguars ran for 341 yards.

Over the past three seasons, Maurice Jones-Drew has pilled up 571 yards rushing in six meetings against the Colts and averages 6.3 yards per carry (that’s not a misprint).

David Garrard is healthy and finally has a halfway decent wide receiver to throw to in Torry Holt.

The Jaguars have always played the Colts tough and there’s no reason to think Sunday will be any different.

Despite some issues of their own — namely the offensive line — the Colts’ offense will put up points … we know that. But can the defense flip the switch for the regular season? That’s anyone’s guess.

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